In the 1970s, Dr. Alexander “Sasha” Shulgin significantly contributed to the development and psychopharmaceutical use of MDMA: a catalyst to personal doors entombed or unknown. His widow, co-author, and research partner, Ann—alongside friends, family, and colleagues—gives a guided tour of their life and laboratory, reflecting on how risks and revelations opened a world of compound enlightenment. Stippled with spirituality, sadness, and skepticism, the Shulgins’ chemical love story examines the power of psychedelic psychotherapy, sacred alchemy, and challenging the path of misunderstood resistance.